IS CBD FOR ME?

CBD or Cannabidiol is a non-psychoactive cannabinoid found in both hemp and cannabis. Use of CBD requires no Medical Marijuana card or certification, and the passing of the Hemp Farming Act in 2018 now makes the use of CBD-rich products derived from hemp legal across the country.

Health Benefits of CBD:

Much of the buzz about CBD is focused in three main areas:

Inflammation, Neuroprotection, Immune Support

Inflammation

Inflammation is at the root of many disease processes in the body and can be a major cause of pain. 

Recent studies suggest that CBD may have a use in treating a number of diseases and disorders known to involve activation of the immune system and oxidative stress as a contributor to disease progression. These include rheumatoid arthritis, Diabetes types I & II, atherosclerosis, Alzheimer’s disease, hypertension, metabolic syndrome, ischemia-reperfusion injury, depression, and neuropathic pain.

Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress

George W. Booz

Free Radic Biol Med. Author manuscript; available in PMC 2012 Sep 1.

Published in final edited form as: Free Radic Biol Med. 2011 Sep 1; 51(5): 1054–1061. Published online 2011 Jan 14. doi: 10.1016/j.freeradbiomed.2011.01.007

PMCID: PMC3085542

Neuroprotection

 Brain health and nerve function are tied to numerous functions of the body. Neuroprotection refers to mental/emotional functions, neuropathic pain, as well as neurodegenerative conditions like dementia and Parkinson’s disease. 

CBD research in animal models and humans has shown numerous therapeutic properties for brain function and protection, both by its effect on the Endocannabinoid system directly and by influencing endogenous cannabinoids. Broadly, CBD has demonstrated anxiolytic, antidepressant, neuroprotective ant-iinflammatory, and immunomodulatory benefits. CBD decreases the production of inflammatory cytokines, influences microglial cells to return to a ramified state, preserves cerebral circulation during ischemic events, and reduces vascular changes and neuroinflammation.  CBD is of particular interest due to its wide-ranging capabilities and lack of side effects in a variety of neurological conditions and diseases.

CBD appears to stimulate synaptic plasticity and facilitates neurogenesis that may explain its positive effects on attenuating psychotic, anxiety, and depressive behaviors. 

Camposa AC, Fogac MV, Sonegoa AB, Guimarãesa FS. Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacol Res. 2016;112:119–27. [PubMed] 

Review of the neurological benefits of phytocannabinoids

Joseph Maroon, Jeff Bost

Surg Neurol Int. 2018; 9: 91. Published online 2018 Apr 26. doi: 10.4103/sni.sni_45_18

PMCID: PMC5938896

Immune Support

Immune function is critical to maintaining optimal health. Immune modulation is the calming of an overactive immune response like you might see in an autoimmune condition like rheumatoid arthritis, or the boosting of a weakened immune system like you might see with cancer or diabetes type II.

Endocannabinoids exhibit complex regulatory effects on the immune system. Endocannabnoids and their congeners can thus be considered as potent immunomodulators. 

Endocannabinoids and immune regulation

Rupal Pandey, Khalida Mousawy, Mitzi Nagarkatti, Prakash Nagarkatti

Pharmacol Res. Author manuscript; available in PMC 2011 Feb 24.

Published in final edited form as: Pharmacol Res. 2009 Aug; 60(2): 85–92. Published online 2009 Apr 7. doi: 10.1016/j.phrs.2009.03.019

PMCID: PMC3044336

CBD has become a popular treatment for many ailments. Although there is still much to learn about its potential medical applications, clinical trials are currently underway for:

  • Chronic Back Pain
  • Osteoarthritis
  • Parkinson’s Disease
  • Alzheimer’s Disease
  • Crohn’s Disease
  • Chronic Back Pain
  • Osteoarthritis
  • Parkinson’s Disease
  • Alzheimer’s Disease
  • Crohn’s Disease
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