Brain health and nerve function are tied to numerous functions of the body. Neuroprotection refers to mental/emotional functions, neuropathic pain, as well as neurodegenerative conditions like dementia and Parkinson’s disease.Â
CBD research in animal models and humans has shown numerous therapeutic properties for brain function and protection, both by its effect on the Endocannabinoid system directly and by influencing endogenous cannabinoids. Broadly, CBD has demonstrated anxiolytic, antidepressant, neuroprotective ant-iinflammatory, and immunomodulatory benefits. CBD decreases the production of inflammatory cytokines, influences microglial cells to return to a ramified state, preserves cerebral circulation during ischemic events, and reduces vascular changes and neuroinflammation. CBD is of particular interest due to its wide-ranging capabilities and lack of side effects in a variety of neurological conditions and diseases.
CBD appears to stimulate synaptic plasticity and facilitates neurogenesis that may explain its positive effects on attenuating psychotic, anxiety, and depressive behaviors.Â
Camposa AC, Fogac MV, Sonegoa AB, GuimarĂŁesa FS. Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacol Res. 2016;112:119–27. [PubMed]Â
–Review of the neurological benefits of phytocannabinoids
Joseph Maroon, Jeff Bost
Surg Neurol Int. 2018; 9: 91. Published online 2018 Apr 26. doi: 10.4103/sni.sni_45_18
PMCID: PMC5938896